40 grams Bulk Fenbendazole

40,000 mgs = 40 grams

$84.99

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From Wikipedia, the free encyclopedia

Fenbendazole (Hoechst brand names Panacur and Safe-Guard, IntervetPanacur and Panacur Rabbit) is a broad spectrum benzimidazole anthelminticused against gastrointestinal parasites including: giardia, roundworms,hookworms, whipworms, the Taenia genus of tapeworms (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms,aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if salicylanilides like dibromsalan and niclosamide are co-administered. Abortions in cattle and death in sheep have been reported.[1]

Toxicity

Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves) and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppression, intestinal crypt cell necrosis and distal villi sloughing.[citation needed] Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.[citation needed]

Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD50 in laboratory animals exceeds 10 g/kg when administered orally.[1]

Metabolism

It gets metabolized in the liver to oxfendazole, which is anthelmintic too; oxfendazole partially gets reduced back to fenbendazole in the liver and rumen.[2][3] Also, fenbendazole itself is an active metabolite of another anthelmintic drug,febantel.[4]